This form of biopsy is a very accurate way to evaluate suspicious masses within the breast that are visible on ultrasound, whether or not they can be felt on breast self-examination or clinical examination. The procedure, which is minimally invasive, also eliminates radiation exposure that comes from using stereotactic biopsy. Tissue specimens are removed using either an automatic spring-loaded or vacuum-assisted device (VAD).

The procedure is used most often to determine whether tissue is benign or malignant. In some cases using VAD, radiologists may be able to remove the entire lesion. Ultrasound-guided biopsy is normally faster than stereotactic-guided breast biopsy and it is possible for the radiologist to follow the motion of the needle as it moves through the breast to the suspicious site. Another benefit is that this form of biopsy can evaluate lumps under the arm or close to the chest wall, unlike stereotactic biopsy.